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Relevant Papers

Warning signs of PIDs in infants

  1. Severe and/or persistent fungal, viral or bacterial infections
  2. Adverse reaction to alive vaccine, particularly to BCG
  3. Persistent diabetes mellitus or other autoimmune/ inflammatory manifestation
  4. Sepsis-like clinical picture without microbial isolation
  5. Extensive skin lesions
  6. Persistent diarrhoea
  7. Congenital heart defects (mainly conotruncal anomalies)
  8. Delayed umbilical cord detachment (> 30 days)
  9. Familial hystory of PID or early deaths due to infection
  10. Persistente lymphocytopenia, or other cytopenia, or leukocytosis without infection
  11. Hypocalcemia with or without seizures
  12. Absence of thymic shadow at X-Ray

Source: proponents: Carneiro-Sampaio, Jacob & Leone. Ped Allergy & Immunol . 2011; 22:345

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